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Article

Lineage-Specific Promoter DNA Methylation Patterns Segregate Adult Progenitor Cell Types

3 Nov 2009

Abstract excerpt

Mesenchymal stem cells (MSCs) can differentiate into multiple mesodermal cell types in vitro; however, their differentiation capacity is influenced by their tissue of origin. To what extent epigenetic information on promoters of lineage-specification genes in human progenitors influences transcriptional activation and differentiation potential remains unclear. We produced bisulfite sequencing maps of DNA...

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PMID: 19886822
DOI: 10.1089/scd.2009.0309

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