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Article

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

Neurobiology of aging - 1 Jun 2010

Jo Dong-Gyu, Arumugam Thiruma V, Woo Ha-Na, Park Jong-Sung, Tang Sung-Chun, Mughal Mohamed, Hyun Dong-Hoon, Park Jun-Hyung, Choi Yun-Hyung, Gwon A-Ryeong, Camandola Simonetta, Cheng Aiwu, Cai Huaibin, Song Weihong, Markesbery William R, Mattson Mark P

Abstract excerpt

Beta-secretase (BACE1), an enzyme responsible for the production of amyloid beta-peptide (Abeta), is increased by oxidative stress and is elevated in the brains of patients with sporadic Alzheimer's disease (AD). Here, we show that oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors. Oxidative...

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Identifiers

PMID: 18687504
DOI: 10.1016/j.neurobiolaging.2008.07.003
PMCID: PMC2858254

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.PMID 18687504Read ↗

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