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Article

Mitochondrial pharmacogenomics: barcode for antibiotic therapy.

Drug discovery today - 1 Jan 2010

Pacheu-Grau David, Gómez-Durán Aurora, López-Pérez Manuel J, Montoya Julio, Ruiz-Pesini Eduardo

Abstract excerpt

Ribosomal RNA (rRNA)-targeting drugs inhibit protein synthesis and represent effective antibiotics for the treatment of infectious diseases. Given the bacterial origins of mitochondria, the molecular and structural components of the protein expression system are much alike. Moreover, the mutational rate of mitochondrial rRNAs is higher than that of nuclear rRNAs, and some of these mutations might simulate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19883791
DOI: 10.1016/j.drudis.2009.10.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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