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Article

Intravenous immunoglobulins--understanding properties and mechanisms.

Clinical and experimental immunology - 1 Dec 2009

Durandy A, Kaveri S V, Kuijpers T W, Basta M, Miescher S, Ravetch J V, Rieben R

Abstract excerpt

High-dose intravenous immunoglobulin (IVIg) preparations are used currently for the treatment of autoimmune or inflammatory diseases. Despite numerous studies demonstrating efficacy, the precise mode of action of IVIg remains unclear. Paradoxically, IgG can exert both pro- and anti-inflammatory activities, depending on its concentration. The proinflammatory activity of low-dose IVIg requires complement activation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19883419
DOI: 10.1111/j.1365-2249.2009.04022.x
PMCID: PMC2801035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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