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Article

Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.

Journal of medicinal chemistry - 26 Nov 2009

Su Dai-Shi, Lim John J, Tinney Elizabeth, Wan Bang-Lin, Young Mary Beth, Anderson Kenneth D, Rudd Deanne, Munshi Vandna, Bahnck Carolyn, Felock Peter J, Lu Meiquing, Lai Ming-Tain, Touch Sinoeun, Moyer Gregory, DiStefano Daniel J, Flynn Jessica A, Liang Yuexia, Sanchez Rosa, Perlow-Poehnelt Rebecca, Miller Mike, Vacca Joe P, Williams Theresa M, Anthony Neville J

Abstract excerpt

Biaryl ethers were recently reported as potent NNRTIs. Herein we disclose a detailed SAR study that led to the biaryl ether 6. This compound possessed excellent potency against WT RT and key clinically observed RT mutants and had an excellent pharmacokinetic profile in rats, dogs, and rhesus macaques. The compound also exhibited a clean safety profile in preclinical safety studies.

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Identifiers

PMID: 19883100
DOI: 10.1021/jm901230r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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