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Article

Diphenyl ether non-nucleoside reverse transcriptase inhibitors with excellent potency against resistant mutant viruses and promising pharmacokinetic properties.

ChemMedChem - 1 Jan 2009

Sweeney Zachary K, Kennedy-Smith Joshua J, Wu Jeffrey, Arora Nidhi, Billedeau J Roland, Davidson James P, Fretland Jennifer, Hang Julie Q, Heilek Gabrielle M, Harris Seth F, Hirschfeld Donald, Inbar Petra, Javanbakht Hassan, Jernelius Jesper A, Jin Qingwu, Li Yu, Liang Weiling, Roetz Ralf, Sarma Keshab, Smith Mark, Stefanidis Dimitrio, Su Guoping, Suh Judy M, Villaseñor Armando G, Welch Michael, Zhang Fang-Jie, Klumpp Klaus

Abstract excerpt

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI-based regimens are efficacious, but the most popular NNRTIs have a low genetic barrier to resistance and have been associated with adverse events. T...

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Identifiers

PMID: 19006142
DOI: 10.1002/cmdc.200800262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19006142-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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