Article
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorganic & medicinal chemistry letters - 1 May 2008
Tucker Thomas J, Saggar Sandeep, Sisko John T, Tynebor Robert M, Williams Theresa M, Felock Peter J, Flynn Jessica A, Lai Ming-Tain, Liang Yuexia, McGaughey Georgia, Liu Meiquing, Miller Mike, Moyer Gregory, Munshi Vandna, Perlow-Poehnelt Rebecca, Prasad Sridhar, Sanchez Rosa, Torrent Maricel, Vacca Joseph P, Wan Bang-Lin, Yan Youwei
Abstract excerpt
Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.
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