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Article

Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

8 Nov 2012

Abstract excerpt

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the...

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PMID: 23137340
DOI: 10.1021/jm301294g

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