Article
Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population.
Lupus - 1 Dec 2009
Lin Y-J, Wan L, Huang C-M, Chen S-Y, Huang Y-C, Lai C-H, Lin W-Y, Liu H-P, Wu Y-S, Chen C-M, Tsai Y-H, Tsai C-H, Sheu J J-C, Tsai F-J
Abstract excerpt
XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) and systemic lupus erythematosus (SLE) in the Taiwanese Han Chinese population. Genotyping was...
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