Article
Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (x-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia.
Genetic testing and molecular biomarkers - 1 Apr 2012
Duman Nilgün, Aktan Melih, Ozturk Sukru, Palanduz Sukru, Cakiris Aris, Ustek Duran, Ozbek Ugur, Nalcaci Meliha, Cefle Kivanc
Abstract excerpt
Polymorphisms of the x-ray repair cross-complementing group 1 (XRCC1) gene have been reported to be associated with various forms of cancer. We evaluated the possible effects of the Arg194Trp and the Arg399Gln polymorphisms on the risk for chronic lymphocytic leukemia (CLL) in 73 patients and 50 controls. We also analyzed their relation to frequency of sister chromatid exchange (SCE). With respect to codon 194,...
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