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Article

Inhibition of interleukin-2 production in the human T cell line JURKAT by nonpolar maleimides.

Toxicology and applied pharmacology - 1 Jan 1991

Freed B M, Lempert N, Lawrence D A

Abstract excerpt

The immunosuppressive properties of polar and nonpolar maleimides were studied by measuring their ability to inhibit mitogen-induced interleukin-2 (IL-2) production by JURKAT T cells. The nonpolar maleimides N-ethylmaleimide (NEM) and N-phenylmaleimide (NPM) inhibited IL-2 production by 85-99%, but only when added to JURKAT cells prior to the mitogen. The polar maleimides N-hydroxymaleimide (NHM) and...

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Source

Identifiers

PMID: 1987656
DOI: 10.1016/0041-008x(91)90341-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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