Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of interleukin-2 production in the human T cell line JURKAT by nonpolar maleimides.

Toxicology and applied pharmacology - 1 Jan 1991

Freed B M, Lempert N, Lawrence D A

Abstract excerpt

The immunosuppressive properties of polar and nonpolar maleimides were studied by measuring their ability to inhibit mitogen-induced interleukin-2 (IL-2) production by JURKAT T cells. The nonpolar maleimides N-ethylmaleimide (NEM) and N-phenylmaleimide (NPM) inhibited IL-2 production by 85-99%, but only when added to JURKAT cells prior to the mitogen. The polar maleimides N-hydroxymaleimide (NHM) and...

Topics

Antibodies, Monoclonal
Calcium
Cell Division
Ethylmaleimide
Humans
Interleukin-2
Lymphocyte Activation
Maleimides
Phenotype
Phytohemagglutinins
Sulfhydryl Compounds
T-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Tumor Cells, Cultured

Source

Identifiers

PMID: 1987656
DOI: 10.1016/0041-008x(91)90341-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1987656-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Inhibition of interleukin-2 production in the human T cell line JURKAT by nonpolar maleimides.PMID 1987656Read ↗

Triethyllead-induced inhibition of proliferation of normal human lymphocytes through decreased expression of the Tac chain of interleukin 2 receptor.Semantic proximity Read ↗

Selective modulation of gene expression in activated normal human peripheral blood mononuclear cells by store-operated calcium entry blocker BTP2Semantic proximity Read ↗

Polymer of methyl malonic acid suppress inflammation by downregulating IL-2 through ROS overproductionSemantic proximity Read ↗

Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeuticsSemantic proximity Read ↗

Modulation of phenotypic and functional maturation of murine bone-marrow-derived dendritic cells (BMDCs) induced by cadmium chloride.Semantic proximity Read ↗

A Human PBMC-Based New Approach Method Reveals PFAS-Driven T-Cell Proliferation and Immune DysregulationSemantic proximity Read ↗

Mycophenolic acid interferes the transcriptional regulation and protein trafficking of maturation surface markers in dendritic cells.Semantic proximity Read ↗

CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.