Article
Triethyllead-induced inhibition of proliferation of normal human lymphocytes through decreased expression of the Tac chain of interleukin 2 receptor.
International journal of immunopharmacology - 1 Jan 1990
Stournaras C, Spanakis E, Perraki M, Athanasiou M, Thanos D, Georgoulias V
Abstract excerpt
Triethyllead (Et3Pb+) in concentrations 10(-5) to 10(-6) M has been shown to inhibit several key cellular molecular systems. In order to evaluate the effect of Et3Pb+ on the human immune system, the mitogen-induced cell proliferation of peripheral blood mononuclear cells was studied in the presence of Et3Pb+. Preincubation of normal T-lymphocytes with 10(-6) M Et3Pb+ for 1-4 h, which has been shown to be...
Topics
- Blotting, Northern
- Cell Division
- Cell Survival
- Dose-Response Relationship, Drug
- Gene Expression Regulation
- Humans
- Interleukin-2
- Lymphocyte Activation
- Organometallic Compounds
- Phenotype