Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon.

doi:10.1126/science.1987637

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon.

Science (New York, N.Y.) - 11 Jan 1991

Tuomanen E, Lindquist S, Sande S, Galleni M, Light K, Gage D, Normark S

Abstract excerpt

The amp operon, which is located on the Escherichia coli chromosome, modulates the induction of plasmid-borne beta-lactamase genes by extracellular beta-lactam antibiotics. This suggests that the gene products AmpD and AmpE may function in the transduction of external signals. beta-Lactam antibiotics are analogs of cell wall components that can be released during cell wall morphogenesis of enterobacteria. The amp...

Topics

Amino Acid Sequence
Bacterial Proteins
Carboxypeptidases
Cell Wall
Diaminopimelic Acid
Enzyme Induction
Escherichia coli
Gene Expression Regulation
Genotype
Membrane Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

N-Acetylmuramoyl-L-alanine Amidase

Oligopeptides

Operon

Peptidoglycan

Plasmids

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1987637
DOI: 10.1126/science.1987637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1987637-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon.PMID 1987637Read ↗

Cell Wall Recycling-Linked Coregulation of AmpC and PenB β-Lactamases through ampD Mutations in Burkholderia cenocepacia.Semantic proximity Read ↗

Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli.Semantic proximity Read ↗

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa.Semantic proximity Read ↗

Genetic control of beta-lactamase production in Enterobacter cloacae.Semantic proximity Read ↗

Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria.Semantic proximity Read ↗

Genetic basis of induction and overproduction of chromosomal class I beta-lactamase in nonfastidious gram-negative bacilli.Semantic proximity Read ↗

Sequences of wild-type and mutant ampD genes of Citrobacter freundii and Enterobacter cloacae.Semantic proximity Read ↗

The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers.Semantic proximity Read ↗

The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli.Semantic proximity Read ↗

Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.Semantic proximity Read ↗

AmpD is required for regulation of expression of NmcA, a carbapenem-hydrolyzing beta-lactamase of Enterobacter cloacae.Semantic proximity Read ↗

Mutations in ampG or ampD affect peptidoglycan fragment release from Neisseria gonorrhoeae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.