Article
Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon.
Science (New York, N.Y.) - 11 Jan 1991
Tuomanen E, Lindquist S, Sande S, Galleni M, Light K, Gage D, Normark S
Abstract excerpt
The amp operon, which is located on the Escherichia coli chromosome, modulates the induction of plasmid-borne beta-lactamase genes by extracellular beta-lactam antibiotics. This suggests that the gene products AmpD and AmpE may function in the transduction of external signals. beta-Lactam antibiotics are analogs of cell wall components that can be released during cell wall morphogenesis of enterobacteria. The amp...
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