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Article

Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology.

Cancer research - 15 Dec 1995

Thrash-Bingham C A, Salazar H, Freed J J, Greenberg R E, Tartof K D

Abstract excerpt

A comprehensive genome scan for loss of heterozygosity (LOH) in 33 renal cell carcinomas indicates that mutations of tumor suppressor genes on several different chromosomes are required for malignant transformation in this disease. In the case of nonpapillary renal carcinomas chromosomes 3p, 6q, 8p, 9pq, and 14q exhibit elevated levels of LOH. Although 3p is the most frequently lost chromosome arm, in no case is...

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Identifiers

PMID: 8521412

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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