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Article

Pathogenic mechanism of the K141E mutation in HSPB8: Insights from smFRET and simulations.

Cell stress & chaperones - 1 Jul 2025

Montepietra Daniele, Bjarnason Sveinn, Óskarsson Kristinn R, Cecconi Ciro, Carra Serena, Heidarsson Pétur O, Brancolini Giorgia

Abstract excerpt

Pathogenic mutations can have a large impact on the conformational ensemble of intrinsically disordered proteins, but revealing those effects and their physiological relevance can be challenging. We used large-scale all-atom explicit-solvent molecular dynamics simulations and single-molecule Förster resonance energy transfer (smFRET) experiments to investigate the conformational dynamics of the chaperone protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40449653
DOI: 10.1016/j.cstres.2025.100086
PMCID: PMC12192327

Genes

HSPB8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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