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Article

Sequence variation at multiple loci influences red cell hemoglobin concentration.

Blood - 16 Dec 2010

Peters Luanne L, Shavit Jordan A, Lambert Amy J, Tsaih Shirng-Wern, Li Qian, Su Zhiguang, Leduc Magalie S, Paigen Beverly, Churchill Gary A, Ginsburg David, Brugnara Carlo

Abstract excerpt

A substantial genetic contribution underlies variation in baseline peripheral blood counts. We performed quantitative trait locus/loci analyses to identify chromosome regions harboring genes influencing red cell hemoglobin concentration using the cell hemoglobin concentration mean (CHCM), a directly measured parameter analogous to the mean cell hemoglobin concentration. Fourteen significant loci (gene symbols...

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Identifiers

PMID: 20833975
DOI: 10.1182/blood-2010-05-283879
PMCID: PMC3031420

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