Article
Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2010
Lohoff Falk W, Ferraro Thomas N, Brodkin Edward S, Weller Andrew E, Bloch Paul J
Abstract excerpt
Genetic linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The metallophosphoesterase (MPPE1) gene maps to this region. Dysregulation of protein phosphorylation and subsequent abnormal cellular signaling has been postulated to be involved in...
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