The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity.

doi:10.1016/j.pnpbp.2011.11.014

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity.

Progress in neuro-psychopharmacology & biological psychiatry - 27 Apr 2012

Kim Se Hyun, Shin Soon Young, Lee Kyu Young, Joo Eun Jeong, Song Joo Youn, Ahn Yong Min, Lee Young Han, Kim Yong Sik

Abstract excerpt

The dual-specificity phosphatase 6 (DUSP6) gene resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK). Previously, we reported a positive association between the functional Leu114Val polymorphism (rs2279574) in DUSP6 and bipolar disorder. Given that the association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to Enzyme Activation

Share to Genetic Association Studies

Share to HeLa Cells

Share to MAP Kinase Signaling System

Share to Polymorphism, Single Nucleotide

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 22155192
DOI: 10.1016/j.pnpbp.2011.11.014

Genes

DUSP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity.PMID 22155192Read ↗

Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler.Semantic proximity Read ↗

Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia.Semantic proximity Read ↗

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.Semantic proximity Read ↗

The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects: control by depolarization and lithiumSemantic proximity Read ↗

Polymorphisms in seizure 6-like gene are associated with bipolar disorder I: evidence of gene × gender interaction.Semantic proximity Read ↗

Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.Semantic proximity Read ↗

The regulation of tetraspanin 8 gene expression-A potential new mechanism in the pathogenesis of bipolar disorder.Semantic proximity Read ↗

Transcription factor SP4 is a susceptibility gene for bipolar disorder.Semantic proximity Read ↗

Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.Semantic proximity Read ↗

An investigation of candidate regions for association with bipolar disorder.Semantic proximity Read ↗

PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.Semantic proximity Read ↗

Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.