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Article

Characterization of a conditional bosR mutant in Borrelia burgdorferi.

Infection and immunity - 1 Jan 2010

Hyde Jenny A, Shaw Dana K, Smith Roger, Trzeciakowski Jerome P, Skare Jon T

Abstract excerpt

Borrelia burgdorferi, the etiological agent of Lyme disease, adapts to unique host environments as a consequence of its complex life cycle that spans both arthropod and mammalian species. In this regard, B. burgdorferi must adapt to various environmental signals, pHs, temperatures, and O(2) and CO(2) levels to establish infectious foci. We hypothesize that the BosR protein functions as a global regulator that is...

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Identifiers

PMID: 19858309
DOI: 10.1128/IAI.01018-09
PMCID: PMC2798208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a conditional bosR mutant in Borrelia burgdorferi.PMID 19858309Read ↗

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirocheteSemantic proximity Read ↗

A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.Semantic proximity Read ↗

Transcriptional profiling of Borrelia burgdorferi containing a unique bosR allele identifies a putative oxidative stress regulon.Semantic proximity Read ↗

BosR (BB0647) governs virulence expression in Borrelia burgdorferiSemantic proximity Read ↗

Who is the BosR around here anyway?Semantic proximity Read ↗

<i>Borrelia</i> oxidative stress response regulator, BosR: A distinctive Zn-dependent transcriptional activatorSemantic proximity Read ↗

<i><scp>B</scp>orrelia burgdorferi</i> oxidative stress regulator <scp>BosR</scp> directly represses lipoproteins primarily expressed in the tick during mammalian infectionSemantic proximity Read ↗

Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.Semantic proximity Read ↗

The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferiSemantic proximity Read ↗

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogenSemantic proximity Read ↗

CsrA Modulates Levels of Lipoproteins and Key Regulators of Gene Expression Critical for Pathogenic Mechanisms of Borrelia burgdorferiSemantic proximity Read ↗

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogenSemantic proximity Read ↗

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