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Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen

28 Jan 2025

Abstract excerpt

ABSTRACT In Borrelia burgdorferi , the causative agent of Lyme disease, differential gene expression is primarily governed by the alternative sigma factor RpoS (σ S ). Understanding the regulation of RpoS is crucial for elucidating how B. burgdorferi is maintained throughout its enzootic cycle. Our recent studies have shown that the homolog of Fur/PerR repressor/activator BosR functions as an RNA-binding protein...

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PMID: 39873484
DOI: 10.1128/mbio.02766-24

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