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Article

Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.

Molecular microbiology - 1 Apr 2013

Miller Christine L, Karna S L Rajasekhar, Seshu J

Abstract excerpt

The RpoS transcription factor of Borrelia burgdorferi is a 'gatekeeper' because it activates genes required for spirochaetes to transition from tick to vertebrate hosts. However, it remains unknown how RpoS becomes repressed to allow the spirochaetes to transition back from the vertebrate host to the tick vector. Here we show that a putative carbohydrate-responsive regulatory protein, designated BadR (Borrelia...

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PMID: 23387366
DOI: 10.1111/mmi.12171
PMCID: PMC4828661

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