Article
Regulation of biofilm formation by sigma B is a common mechanism in Staphylococcus epidermidis and is not mediated by transcriptional regulation of sarA.
The International journal of artificial organs - 1 Sept 2009
Jäger Sebastian, Jonas Beate, Pfanzelt Dorothea, Horstkotte Matthias A, Rohde Holger, Mack Dietrich, Knobloch Johannes K-M
Abstract excerpt
Biofilm formation is a major pathogenetic factor of Staphylococcus epidermidis. In S. epidermidis the alternative sigma factor sigma B was identified to regulate biofilm formation in S. epidermidis 1457. In S. aureus sigma B dependent regulation plays a minor role, whereas sarA (Staphylococcus accessory regulator) is an essential regulator. Therefore, we investigated the impact of sigma B on sarA transcription...
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