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Article

Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation.

PloS one - 24 May 2010

Beenken Karen E, Mrak Lara N, Griffin Linda M, Zielinska Agnieszka K, Shaw Lindsey N, Rice Kelly C, Horswill Alexander R, Bayles Kenneth W, Smeltzer Mark S

Abstract excerpt

BACKGROUND: The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is mounting evidence to suggest that these opposing roles are therapeutically relevant in that mutation of agr results in increased biofilm formation and decreased antibiotic susceptibility while mutation of sarA has the opposite effect. To the extent...

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Identifiers

PMID: 20520723
DOI: 10.1371/journal.pone.0010790
PMCID: PMC2875390

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Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation.PMID 20520723Read ↗

Strain-Dependent Differences in the Regulatory Roles of sarA and agr in Staphylococcus aureusSemantic proximity Read ↗

Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic StrategiesSemantic proximity Read ↗

saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus.Semantic proximity Read ↗

Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants.Semantic proximity Read ↗

Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) SystemSemantic proximity Read ↗

Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model.Semantic proximity Read ↗

sarA negatively regulates S taphylococcus epidermidis biofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis‐dependent release of eDNASemantic proximity Read ↗

Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis.Semantic proximity Read ↗

Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion.Semantic proximity Read ↗

The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus.Semantic proximity Read ↗

Nonconformity of biofilm formation in vivo and in vitro based on Staphylococcus aureus accessory gene regulator statusSemantic proximity Read ↗

Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation.Semantic proximity Read ↗

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