Article
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia.
European archives of psychiatry and clinical neuroscience - 1 Mar 2010
Schmitt Andrea, Koschel Jiri, Zink Mathias, Bauer Manfred, Sommer Clemens, Frank Josef, Treutlein Jens, Schulze Thomas, Schneider-Axmann Thomas, Parlapani Eleni, Rietschel Marcella, Falkai Peter, Henn Fritz A
Abstract excerpt
To determine if NMDA receptor alterations are present in the cerebellum in schizophrenia, we measured NMDA receptor binding and gene expression of the NMDA receptor subunits in a post-mortem study of elderly patients with schizophrenia and non-affected subjects. Furthermore, we assessed influence of genetic variation in the candidate gene neuregulin-1 (NRG1) on the expression of the NMDA receptor in an...
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