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Article

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs.

Blood - 17 Dec 2009

Aichberger Karl J, Gleixner Karoline V, Mirkina Irina, Cerny-Reiterer Sabine, Peter Barbara, Ferenc Veronika, Kneidinger Michael, Baumgartner Christian, Mayerhofer Matthias, Gruze Alexander, Pickl Winfried F, Sillaber Christian, Valent Peter

Abstract excerpt

Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In most cases, neoplastic cells display the D816V-mutated variant of KIT. KIT D816V exhibits constitutive tyrosine kinase (TK) activity and has been implicated in increased survival and growth of neoplastic MCs. Recent data suggest that the proapoptotic BH3-only death regulator Bim plays a role as a tumor suppressor...

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Source

Identifiers

PMID: 19850739
DOI: 10.1182/blood-2008-08-175190

Genes

KIT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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