Article
Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
BMC medical genetics - 26 Jul 2008
Alsmadi Osama, Al-Rubeaan Khalid, Mohamed Gamal, Alkayal Fadi, Al-Saud Haya, Al-Saud Nouran Abu, Al-Daghri Nasser, Mohammad Shahinaz, Meyer Brian F
Abstract excerpt
BACKGROUND: The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. Meta-analysis of 27 different studies has resulted in a global OR of 1.46 [1.42-1.51] (rs7903146 variant). Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established. METHODS: We performed a case-control...
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