Article
Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants.
Clinical and vaccine immunology : CVI - 1 Dec 2009
Dirix V, Verscheure V, Goetghebuer T, Hainaut M, Debrie A S, Locht C, Mascart F
Abstract excerpt
Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here...
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