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Evaluation of pyrosequencing for extensive drug resistance-defining anti-tuberculosis drugs for use in public healthcare.

Tuberculosis (Edinburgh, Scotland) - 1 May 2018

Nambiar Remya, Shah Daksha, Ajbani Kanchan, Kazi Mubin, Sadani Meeta, Shetty Anjali, Keskar Padmaja, Kamble Sanjeev, van Belkum Alex, Rodrigues Camilla

Abstract excerpt

MGIT 960 drug susceptibility testing (DST) for Mycobacterium tuberculosis was compared for performance and speed with pyrosequencing (PSQ). Pulmonary samples (n = 100), from GeneXpert/MTB/Rifampicin-resistant patients receiving second-line treatment for 1-3 months, were subjected to DST and PSQ for seven drugs (isoniazid, rifampicin, kanamycin, amikacin, capreomycin, moxifloxacin, and ofloxacin). The mean...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29779779
DOI: 10.1016/j.tube.2018.03.006

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DST

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