Article
Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin.
Hepatology (Baltimore, Md.) - 1 Dec 2009
Romero-Gómez Manuel, Diago Moisés, Andrade Raúl J, Calleja José L, Salmerón Javier, Fernández-Rodríguez Conrado M, Solà Ricard, García-Samaniego Javier, Herrerías Juan M, De la Mata Manuel, Moreno-Otero Ricardo, Nuñez Oscar, Olveira Antonio, Durán Santiago, Planas Ramón
Abstract excerpt
UNLABELLED: Insulin resistance affects sustained virological response (SVR) in chronic hepatitis C. To know whether adding metformin to standard antiviral treatment improves SVR, we conducted a prospective, multicentered, randomized, double-blinded, placebo-controlled trial in 19 Spanish hospitals, including 123 consecutive patients with genotype 1 chronic hepatitis C and insulin resistance. Patients were...
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