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Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin.

Hepatology (Baltimore, Md.) - 1 Aug 2012

Harrison Stephen A, Hamzeh Fayez M, Han Jian, Pandya Prashant K, Sheikh Muhammed Y, Vierling John M

Abstract excerpt

UNLABELLED: Patients with chronic hepatitis C and insulin resistance are less likely to respond to anti-hepatitis C virus (HCV) therapy and are at risk for more rapid fibrosis progression. Coadministration of pioglitazone with peginterferon/ribavirin improves insulin sensitivity and increases virologic response rates in insulin-resistant HCV genotype 4 patients, but it is unclear whether this finding applies to...

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PMID: 22334369
DOI: 10.1002/hep.25661

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