Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding.

Protein science : a publication of the Protein Society - 1 Dec 2009

West Nathan R, Farnell Benjamin, Murray Jill I, Hof Fraser, Watson Peter H, Boulanger Martin J

Abstract excerpt

S100A7 (psoriasin) is a calcium- and zinc-binding protein implicated in breast cancer. We have shown previously that S100A7 enhances survival mechanisms in breast cells through an interaction with c-jun activation domain binding protein 1 (Jab1), and an engineered S100A7 triple mutant (Asp(56)Gly, Leu(78)Met, and Gln(88)Lys-S100A7(3)) ablates Jab1 binding. We extend these results to include defined breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COP9 Signalosome Complex

Share to Crystallography, X-Ray

Share to Intracellular Signaling Peptides and Proteins

Share to Peptide Hydrolases

Share to Protein Conformation

Share to S100 Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19844956
DOI: 10.1002/pro.274
PMCID: PMC2821279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding.PMID 19844956Read ↗

Mast cell and monocyte recruitment by S100A12 and its hinge domain.Semantic proximity Read ↗

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.Semantic proximity Read ↗

The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer.Semantic proximity Read ↗

Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization.Semantic proximity Read ↗

The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosisSemantic proximity Read ↗

Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.Semantic proximity Read ↗

Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity.Semantic proximity Read ↗

Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC.Semantic proximity Read ↗

S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast.Semantic proximity Read ↗

Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism.Semantic proximity Read ↗

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.Semantic proximity Read ↗

Contributions of the S100A9 C-terminal tail to high-affinity Mn(II) chelation by the host-defense protein human calprotectin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.