Article
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Nature immunology - 1 Jan 2013
Wang Chenhui, Wu Ling, Bulek Katarzyna, Martin Bradley N, Zepp Jarod A, Kang Zizhen, Liu Caini, Herjan Tomasz, Misra Saurav, Carman Julie A, Gao Ji, Dongre Ashok, Han Shujie, Bunting Kevin D, Ko Jennifer S, Xiao Hui, Kuchroo Vijay K, Ouyang Wenjun, Li Xiaoxia
Abstract excerpt
Act1 is an essential adaptor in interleukin 17 (IL-17)-mediated signaling and is recruited to the receptor for IL-17 after stimulation with IL-17. Here we found that Act1 was a 'client' protein of the molecular chaperone hsp90. The D10N variant of Act1 (Act1(D10N)) that is linked to susceptibility to psoriasis was defective in its interaction with hsp90, which resulted in a global loss of Act1 function....
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