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Article

Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.

Antimicrobial agents and chemotherapy - 1 Jan 2010

Karema Corine, Imwong Mallika, Fanello Caterina I, Stepniewska Kasia, Uwimana Aline, Nakeesathit Supatchara, Dondorp Arjen, Day Nicholas P, White Nicholas J

Abstract excerpt

Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlated the efficacy of chlorproguanil-dapsone plus artesunate (CPG-DDS+A) and amodiaquine plus...

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Identifiers

PMID: 19841150
DOI: 10.1128/AAC.00498-09
PMCID: PMC2798539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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