Strategies for mitigating emerging artemisinin-based antimalarial drug resistance in Rwanda: a promising approach for managing therapies in malaria-endemic countries.

doi:10.1136/bmjgh-2025-020884

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Strategies for mitigating emerging artemisinin-based antimalarial drug resistance in Rwanda: a promising approach for managing therapies in malaria-endemic countries.

BMJ global health - 2 Oct 2025

Muvunyi Claude Mambo, Gashema Pierre, Mbituyumuremyi Aimable, Iradukunda Patrick Gad, Siddig Emmanuel Edwar, Niyonzima Jean Damascene, Hakizimana Emmanuel, Umulisa Noella, Noor Abdisalan Mohamed, Mugabo Semahore Jules, Tuyishime Albert, Harelimana Jean de Dieu, Umuhire Jeanne, Butera Yvan, Nsanzimana Sabin

Abstract excerpt

Malaria treatment failures associated with reduced efficacy of chloroquine (CQ) and amodiaquine (AQ) antimalarial drugs emerged in Rwanda during the 1980s, prompting the policy shift towards adopting artemisinin-based combination therapies in 2006 as an alternative. However, recent findings from malaria surveillance and therapeutic efficacy studies have revealed a countrywide increase in antimalarial drug...

Read the complete abstract on PubMed

Topics

Antimalarials
Artemisinins
Humans
Rwanda
Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Plasmodium falciparum

Malaria, Falciparum

Drug Combinations

Mutation

Amodiaquine

Artemether, Lumefantrine Drug Combination

Malaria

Endemic Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 41043959
DOI: 10.1136/bmjgh-2025-020884
PMCID: PMC12496036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strategies for mitigating emerging artemisinin-based antimalarial drug resistance in Rwanda: a promising approach for managing therapies in malaria-endemic countries.PMID 41043959Read ↗

Artemisinin and multidrug-resistant Plasmodium falciparum - a threat for malaria control and elimination.Semantic proximity Read ↗

Mapping Plasmodium falciparum mutations in Africa: A critical review of emerging drug resistance and implications for malaria controlSemantic proximity Read ↗

Impacts of Antimalarial Drugs on Plasmodium falciparum Drug Resistance Markers, Western Kenya, 2003-2015.Semantic proximity Read ↗

Clinical evidence of Kelch13-dependent and -independent malaria treatment failure with Artemether-LumefantrineSemantic proximity Read ↗

What are the effects of drug resistance on the global spread of malaria? A systematic literature reviewSemantic proximity Read ↗

First Detection in West Africa of a Mutation That May Contribute to Artemisinin Resistance Plasmodium falciparumSemantic proximity Read ↗

Assessing the Therapeutic Efficacy of Artemether-Lumefantrine for Uncomplicated Malaria in Lagos, Nigeria: A Comprehensive Study on Treatment Response and Resistance MarkersSemantic proximity Read ↗

In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine Sensitivity.Semantic proximity Read ↗

Assessment of molecular markers of anti-malarial drug resistance among children participating in a therapeutic efficacy study in western KenyaSemantic proximity Read ↗

Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.Semantic proximity Read ↗

Plasmodium falciparum non-synonymous Kelch13 mutations mediating artemisinin resistance in East Africa: A systematic review and meta-analysis: 2014-2024.Semantic proximity Read ↗

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.