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Article

Bcr is a substrate for Transglutaminase 2 cross-linking activity.

BMC biochemistry - 10 Feb 2011

Yi Sun-Ju, Groffen John, Heisterkamp Nora

Abstract excerpt

BACKGROUND: Breakpoint cluster region (Bcr) is a multi-domain protein that contains a C-terminal GTPase activating protein (GAP) domain for Rac. Transglutaminase 2 (TG2) regulates Bcr by direct binding to its GAP domain. Since TG2 has transglutaminase activity that has been implicated in the response to extreme stress, we investigated if Bcr can also act as a substrate for TG2. RESULTS: We here report that...

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Source

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Identifiers

PMID: 21310073
DOI: 10.1186/1471-2091-12-8
PMCID: PMC3044668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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