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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

16 Oct 2009

Abstract excerpt

The hypothesis that amyloid-beta (Abeta) peptides are the primary cause of Alzheimer's disease (AD) remains the best supported theory of AD pathogenesis. Yet, many observations are inconsistent with the hypothesis. Abeta peptides are generated when amyloid precursor protein (APP) is cleaved by presenilins, a process that also produces APP intracellular domain (AICD). We previously generated AICD-overexpressing...

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PMID: 19837693
DOI: 10.1073/pnas.0907652106

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