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Article

Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome

14 Oct 2009

Abstract excerpt

The cause of polycystic ovary syndrome (PCOS), a complex endocrine disorder, is unknown, but its familial aggregation implies underlying genetic influences. Hyperandrogenemia is regarded as a major endocrine character of the PCOS. In this study, we employed bisulfite sequencing and bisulfite restriction analysis to investigate the DNA methylation status of LHR, AR, FSHR and H19 in dehydroepiandrosterone...

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Share to Epigenetics and DNA Methylation
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PMID: 19828691
DOI: 10.1093/molehr/gap089

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