Article
Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell.
Oncotarget - 10 May 2016
Xu Jiawei, Bao Xiao, Peng Zhaofeng, Wang Linlin, Du Linqing, Niu Wenbin, Sun Yingpu
Abstract excerpt
Polycystic ovary syndrome (PCOS) affects approximately 7% of the reproductive-age women. A growing body of evidence indicated that epigenetic mechanisms contributed to the development of PCOS. The role of DNA modification in human PCOS ovary granulosa cell is still unknown in PCOS progression. Global DNA methylation and hydroxymethylation were detected between PCOS' and controls' granulosa cell. Genome-wide DNA...
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