Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells

13 Oct 2009

Abstract excerpt

BACKGROUND: Recently, transcriptional gene silencing induced by small interfering RNA (siRNA) was found in mammalian and human cells. However, previous studies focused on endogenous genes. METHODS: In this study, we designed siRNA targeting the promoter of human papillomavirus 16 E6/E7 and transfected it into the cervical cancer cell line, SiHa. E6 and E7 mRNA and protein expression were detected in cells treated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cervical Cancer and HPV Research
Share to Reproductive tract infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19826423
DOI: 10.1038/sj.bjc.6605344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cellsPMID 19826423Read ↗

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.Semantic proximity Read ↗

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA.Semantic proximity Read ↗

Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cellsSemantic proximity Read ↗

Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer CellsSemantic proximity Read ↗

Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cellsSemantic proximity Read ↗

E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells.Semantic proximity Read ↗

Activation of Wnt Signaling Pathway by Human Papillomavirus E6 and E7 Oncogenes in HPV16-Positive Oropharyngeal Squamous Carcinoma CellsSemantic proximity Read ↗

Suppression of E6 Oncogene Induces Apoptosis in CaSki Cervical Cancer CellsSemantic proximity Read ↗

HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a PathwaySemantic proximity Read ↗

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53Semantic proximity Read ↗

E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factor <i>β</i> <sub>1</sub> Promoter throughout Sp1 Recognition SequenceSemantic proximity Read ↗

Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV‐positive cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.