E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factor β 1 Promoter throughout Sp1 Recognition Sequence

doi:10.1089/vim.2006.19.468

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E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factor β 1 Promoter throughout Sp1 Recognition Sequence

1 Sept 2006

Abstract excerpt

Human Papillomavirus (HPV) infection is the main etiologic agent of cervical cancer and HPV E6 and E7 oncogenes trans-regulate many cellular genes. An association between TGF-beta1 gene expression and cervical cancer development has been suggested; however, the mechanisms by which HPV influences TGF-beta1 expression remain unclear. In the present study we analyzed the mechanism through which HPV-16 E6 and E7...

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PMID: 16987065
DOI: 10.1089/vim.2006.19.468

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E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factor <i>β</i> <sub>1</sub> Promoter throughout Sp1 Recognition Sequence

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