Article
Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells.
Cancer research - 15 Oct 2009
Reim Florian, Dombrowski Yvonne, Ritter Cathrin, Buttmann Mathias, Häusler Sebastian, Ossadnik Monika, Krockenberger Mathias, Beier Dagmar, Beier Christoph P, Dietl Johannes, Becker Jürgen C, Hönig Arnd, Wischhusen Jörg
Abstract excerpt
Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribu...
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