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Article

miR‐200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer

10 Oct 2019

Abstract excerpt

Abstract Resistance to trastuzumab remains a major obstacle in HER2‐overexpressing breast cancer treatment. miR‐200c is important for many functions in cancer stem cells (CSCs), including tumour recurrence, metastasis and resistance. We hypothesized that miR‐200c contributes to trastuzumab resistance and stemness maintenance in HER2‐overexpressing breast cancer. In this study, we used HER2‐positive SKBR3,...

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PMID: 31599500
DOI: 10.1111/jcmm.14681

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