Article
miR-200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer
2017-04-25
Abstract excerpt
Resistance to trastuzumab remains a major obstacle in HER2-overexpressing breast cancer treatment. miR-200c is important for many functions in cancer stem cells (CSCs), including tumor recurrence, metastasis and resistance. We hypothesized that miR-200c contributes to trastuzumab resistance and stemness maintenance in HER2-overexpressing breast cancer. In this study, we used HER2-positive SKBR3, HER2-negative MCF-...
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Identifiers and source
- Literature Corpus work
- b1cc6d2b-7a23-501e-83a1-73df8a803b2a
- DOI
- 10.1101/130682