Article
Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype.
Oncogene - 9 Feb 2012
Jiang J, Zhang Y, Chuai S, Wang Z, Zheng D, Xu F, Zhang Y, Li C, Liang Y, Chen Z
Abstract excerpt
Identification and characterization of cancer stem cells (CSCs) in gastric cancer are difficult owing to the lack of specific markers and consensus methods. In this study, we show that cells with the CD90 surface marker in gastric tumors could be enriched under non-adherent, serum-free and sphere-forming conditions. These CD90(+) cells possess a higher ability to initiate tumor in vivo and could re-establish the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.