Article
Breast cancer: coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs.
Neoplasia (New York, N.Y.) - 1 Sept 2014
Lebel-Haziv Yaeli, Meshel Tsipi, Soria Gali, Yeheskel Adva, Mamon Elad, Ben-Baruch Adit
Abstract excerpt
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design of modalities inhibiting CCL2 secretion and consequently reduce tumorigenicity. Using cells deficient in expression of glycosaminoglycans (GAGs) and short hairpin...
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