Article
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.
PloS one - 12 Oct 2009
Scholl Hendrik P N, Fleckenstein Monika, Fritsche Lars G, Schmitz-Valckenberg Steffen, Göbel Arno, Adrion Christine, Herold Christine, Keilhauer Claudia N, Mackensen Friederike, Mössner Andreas, Pauleikhoff Daniel, Weinberger Andreas W A, Mansmann Ulrich, Holz Frank G, Becker Tim, Weber Bernhard H F
Abstract excerpt
BACKGROUND: Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional...
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