Article
HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes.
Biochemical and biophysical research communications - 4 Aug 2006
Holderfield Matthew T, Henderson Anderson April M, Kokubo Hiroki, Chin Michael T, Johnson Randy L, Hughes Christopher C W
Abstract excerpt
The bHLH transcription factor HESR1 (CHF2) acts downstream of notch to regulate cardiovascular development and angiogenesis, at least in part through down-regulation of the VEGF receptor, VEGFR2. Surprisingly, we find that HESR1 interacts with the promoter in endothelial cells (EC) not through direct binding to the E-boxes, but through intermediary interactions with GC-box-binding proteins. The bHLH and orange...
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