Article
Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes.
PLoS genetics - 1 Jul 2014
Hopkins Jessica, Hwang Grace, Jacob Justin, Sapp Nicklas, Bedigian Rick, Oka Kazuhiro, Overbeek Paul, Murray Steve, Jordan Philip W
Abstract excerpt
Cohesins are important for chromosome structure and chromosome segregation during mitosis and meiosis. Cohesins are composed of two structural maintenance of chromosomes (SMC1-SMC3) proteins that form a V-shaped heterodimer structure, which is bridged by a α-kleisin protein and a stromal antigen (STAG) protein. Previous studies in mouse have shown that there is one SMC1 protein (SMC1β), two α-kleisins (RAD21L and...
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