Article
The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.
The Journal of biological chemistry - 22 Mar 2002
Geib Sandrine, Sandoz Guillaume, Cornet Veronique, Mabrouk Kamel, Fund-Saunier Odile, Bichet Delphine, Villaz Michel, Hoshi Toshinori, Sabatier Jean-Marc, De Waard Michel
Abstract excerpt
We have investigated the molecular mechanisms whereby the I-II loop controls voltage-dependent inactivation in P/Q calcium channels. We demonstrate that the I-II loop is localized in a central position to control calcium channel activity through the interaction with several cytoplasmic sequences; including the III-IV loop. Several experiments reveal the crucial role of the interaction between the I-II loop and...
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