Article
In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis.
Memorias do Instituto Oswaldo Cruz - 1 Aug 2009
Verza Mirela, Maschmann Raquel de Abreu, Silva Márcia Susana Nunes, Dalla Costa Elis Regina, Ribeiro Marta Osório, Rosso Franciele, Suffys Philip Noel, Tortoli Enrico, Marcelli Fiorella, Zaha Arnaldo, Rossetti Maria Lucia Rosa
Abstract excerpt
Mutations in the katG gene have been identified and correlated with isoniazid (INH) resistance in Mycobacterium tuberculosis isolates. The mutation AGC-->ACC (Ser-->Thr) at katG315 has been reported to be the most frequent and is associated with transmission and multidrug resistance. Rapid detection of this mutation could therefore improve the choice of an adequate anti-tuberculosis regimen, the epidemiological...
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